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US 2012/0237945 A1Published application
Chimeric pcsk9 proteins, cells comprising same, and assays using same
AssigneeAdaerata, Limited Partnership
InventorsNABIL G. SEIDAH, JEAN DAVIGNON, GENEVIÉVE DUBUC, LISE BERNIER, MICHEL TREMBLAY
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Abstract
A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.
Claims9
A purified polypeptide, the amino acid sequence of which consists of SEQ ID NO:
- 32.
A purified polypeptide, the amino acid sequence of which consists of SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.