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US 2012/0237941 A1Published application
Method for screening active agents that stimulate the expression of arnt2 to improve the skin's barrier function
AssigneeChanel Parfums Beaute
InventorElena Fedorova
Life of this patent
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Abstract
A method for screening an active agent intended for preventing or combating the cutaneous signs resulting from a non-pathological impairment of the barrier function, which includes the selection of active agents that stimulate the expression of ARNT2 in cultured human keratinocytes.
Claims9
A method for screening active agents, which are able to prevent or combat the cutaneous signs resulting from non-pathological impairment of the barrier function, comprising the following steps:
- a) treating a sample of cultured keratinocytes from a human donor with an active agent, such as a botanical extract;
- b) quantifying the expression of ARNT2 in said treated sample, relative to the same cell sample which has not been treated;
- c) selecting the active agents that provide for an increase in the expression of ARNT2 relative to the untreated sample.
Dependencies are inferred from the claim text.