Methods and materials for assessing the cis/trans nature of humans having cyp2c19*2 and cyp2c19*17 alleles
OwnerJennifer Skierka, Dennis J. O'Kane +1inventors
InventorsJennifer Skierka, Dennis J. O'Kane, John L. Black
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Abstract
This document provides methods and materials involved in determining if a human heterozygous for CYP2C19*2 and heterozygous for CYP2C19*17 contains one CYP2C19 allele with both CYP2C19*2 and CYP2C19*17 (e.g., a cis relationship) or contains one CYP2C19 allele with CYP2C19*2 and one CYP2C19 allele with CYP2C19*17 (e.g., a trans relationship).
Claims20
A method for assessing the cis or trans nature of a human heterozygous for CYP2C19*2 and heterozygous for CYP2C19*17, wherein said method comprises:
- (a) determining if a CYP2C19 allele of said human comprises (i) a T, A, or G at the c.-806 position and a C, A, or G at the c.-98 position, (ii) a C at the c.-806 position and a T at the c.-98 position, (iii) a C at the c.-806 position and a C, A, or G at the c.-98 position, or (iv) a T, A, or G at the c.-806 position and a T at the c.-98 position,
- (b) classifying said human as having CYP2C19*2 and CYP2C19*17 in cis if said CYP2C19 allele comprises (i) or (ii), and
- (c) classifying said human as having CYP2C19*2 and CYP2C19*17 in trans if said CYP2C19 allele comprises (iii) or (iv).
A method for identifying a human heterozygous for CYP2C19*2 and heterozygous for CYP2C19*17 having CYP2C19*2 and CYP2C19*17 in cis, wherein said method comprises:
- (a) detecting the presence of an CYP2C19 allele of said human comprising (i) a T, A, or G at the c.-806 position and a C, A, or G at the c.-98 position or (ii) a C at the c.-806 position and a T at the c.-98 position, and
- (b) classifying said human as having CYP2C19*2 and CYP2C19*17 in cis based at least in part on said presence of said CYP2C19 allele.
A method for identifying a human heterozygous for CYP2C19*2 and heterozygous for CYP2C19*17 having CYP2C19*2 and CYP2C19*17 in trans, wherein said method comprises:
- (a) detecting the presence of an CYP2C19 allele of said human comprising (i) a C at the c.-806 position and a C, A, or G at the c.-98 position or (ii) a T, A, or G at the c.-806 position and a T at the c.-98 position, and
- (b) classifying said human as having CYP2C19*2 and CYP2C19*17 in trans based at least in part on said presence of said CYP2C19 allele.
Dependencies are inferred from the claim text.