Methods of treating hypertriglyceridemia
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorsMehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Abstract
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof
Claims18
A method of reducing triglycerides in a subject in need thereof comprising:
- administering to the subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl about 2 g to per day of a pharmaceutical composition comprising at least about 90%, by weight, ethyl eicosapentaenoate for a period of 12 weeks to effect a reduction in triglycerides compared to a second subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl who has not received the pharmaceutical composition.
A method of reducing triglycerides in a subject with very high triglycerides and in need thereof comprising, administering to the subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl who does not receive concurrent lipid altering therapy about 2 g per day of a pharmaceutical composition comprising at least about 90%, by weight, ethyl eicosapentaenoate for a period of 12 weeks to effect a reduction in fasting triglycerides of at least about 15% without increasing LDL-C compared to a second subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl who does not receive concurrent lipid altering therapy or the pharmaceutical composition.
The method of claim 8, wherein the pharmaceutical composition is administered to the subject 1 to 4 times per day.
The method of claim 9, wherein the pharmaceutical composition is present in one or more capsules.
Dependencies are inferred from the claim text.