Microcapsules produced from blended sol-gel precursors and method for producing the same
AssigneeInternational Flavors & Fragrances Inc.
InventorsYabin Lei, Lewis Michael Popplewell, Xiao Huang, Carol Joyce
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Abstract
The present invention features microcapsule particles with an oil or aqueous liquid core, and shell composed of a blend of metal or semi-metal oxide polymers. Methods for preparing and using the microcapsule particles in personal care, therapeutic, cosmetic and cosmeceutic products are also provided.
Claims77
A microcapsule particle composition comprising:
- (a) a core formed from an oil or aqueous liquid containing at least one active ingredient;
- and
- (b) a shell encapsulating said core, wherein said shell is composed of
- (i) at least one hydrolyzable metal or semi-metal oxide polymer, and
- (ii) at least one metal or semi-metal oxide polymer having a non-hydrolyzable substituent,
- wherein the polymer of (ii) is present in an amount up to 10% of the total weight of the shell.
A process for the preparation of microcapsule particles containing an oil or aqueous liquid core comprising:
- (a) combining, in a sol-gel process:
- (i) an emulsion containing an oil or aqueous liquid;
- and
- (ii) a mixture of at least one hydrolyzable sol-gel precursor and at least one sol-gel precursor having at least one non-hydrolyzable substituent,
- wherein the at least one sol-gel precursor having at least one non-hydrolyzable substituent is present in an amount of up to 10% of the total sol-gel precursor of (ii);
- (b) curing the product of step (a);
- and
- (c) adding a surfactant or polymer to the product of step (b), thereby preparing microcapsule particles containing an oil or aqueous liquid core.
The process of 10, wherein the sol-gel precursor of having at least one non-hydrolyzable substituent is a monomer of the formula:
- M(R)n(P)m, wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, n is an integer from 1 to 6, P is a non-hydrolyzable substituent, and m is and integer from 1 to 6.
The process of 10, wherein the hydrolyzable sol-gel precursor is a monomer of the formula M(R)n:
- wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, and n is an integer from 1 to 6.
A process for the preparation of microcapsule particles containing an oil or aqueous liquid core comprising:
- (a) mixing, in a sol-gel process
- (i) a first emulsion containing an oil or aqueous liquid and at least one sol-gel precursor having at least one non-hydrolyzable substituent;
- and
- (ii) a second emulsion containing at least one hydrolyzable sol-gel precursor,
- wherein the at least one sol-gel precursor of (i) is present in an amount of up to 10% of the total sol-gel precursor of (i) and (ii);
- (b) curing the mixture;
- and
- (c) adding a surfactant or polymer to the product of step (b), thereby preparing microcapsule particles containing an oil or aqueous liquid core.
The process of 27, wherein the sol-gel precursor of (i) is a monomer of the formula:
- M(R)n(P)m, wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, n is an integer from 1 to 6, P is a non-hydrolyzable substituent, and m is and integer from 1 to 6.
The process of 27, wherein the hydrolyzable sol-gel precursor is a monomer of the formula M(R)n:
- wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, and n is an integer from 1 to 6.
A process for the preparation of microcapsule particles containing an oil or aqueous liquid core comprising:
- (a) mixing an oil or aqueous liquid with
- (i) at least one sol-gel precursor having at least one non-hydrolyzable substituent;
- and
- (ii) at least one hydrolyzable sol-gel precursor, wherein the at least one sol-gel precursor of (i) is present in an amount of up to 10% of the total sol-gel precursor of (i) and (ii);
- (b) cooling the mixture of (a) to room temperature;
- (c) adding the mixture of (a) to an emulsifier solution to produce a second mixture;
- (d) homogenizing the second mixture of (c) to produce a homogenized mixture;
- (e) adding a defoamer to the homogenized mixture of (d);
- (f) curing the product of (e), and
- (g) adding a surfactant or polymer to the product of step (f), thereby preparing microcapsule particles containing an oil or aqueous liquid core.
The process of 39, wherein the sol-gel precursor of (i) is a monomer of the formula:
- M(R)n(P)m, wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, n is an integer from 1 to 6, P is a non-hydrolyzable substituent, and m is and integer from 1 to 6.
The process of 39, wherein the hydrolyzable sol-gel precursor is a monomer of the formula M(R)n:
- wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, and n is an integer from 1 to 6.
A microcapsule particle composition comprising:
- (a) a core formed from an oil or aqueous liquid containing at least one active ingredient;
- (b) a shell encapsulating said core, wherein said shell is composed of at least one hydrolyzable metal or semi-metal oxide polymer;
- and
- (c) a surfactant or polymer.
A process for the preparation of microcapsule particles containing an oil or aqueous liquid core comprising:
- (a) combining, in a sol-gel process:
- (i) an emulsion containing an oil or aqueous liquid;
- and
- (ii) at least one hydrolyzable sol-gel precursor;
- (b) curing the product of step (a);
- and
- (c) adding a surfactant or polymer to the product of step (b), thereby preparing microcapsule particles containing an oil or aqueous liquid core.
The process of 59, wherein the hydrolyzable sol-gel precursor is a monomer of the formula M(R)n:
- wherein M is a metallic or a semi-metallic element, R is a hydrolyzable substituent, and n is an integer from 1 to 6.
Dependencies are inferred from the claim text.