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AssigneeTechnion Research & Development Foundation Limited
InventorsAmram Mor, Richard M. Epand, Raquel F. Epand, Brigitte Papahadjopoulos-Sternberg
Estimating the term…
Disclosed are compositions-of-matter comprising polymer-mediated cochleates, which are formed from a calcium-free mixture of a wide variety of phospholipids that are atypical for forming cochleates. Further disclosed are compositions-of-matter comprising these cochleates which co-encapsulate another bioactive agent. The polymer mediating the formation of these cochleates exhibits a plurality of positively charged amino acid residues and omega-amino-fatty acid moieties, and may further exhibit antimicrobial, anticancerous and drug-potentiating activity. Further disclosed are pharmaceutical compositions and methods using the compositions-of-matter disclosed herein, and processes of preparing same.
1-47. (canceled)
A composition-of-matter comprising a cochleate and a polymer encapsulated in said cochleate, said cochleate is being formed from a mixture of at least two phospholipids, and said polymer comprising a plurality of positively charged amino acid residues and at least one ω-amino-fatty acid moiety, said ω-amino-fatty acid moiety is being covalently linked to at least two amino acid residues in said plurality of positively charged amino acid residues via the N-alpha of one amino acid residue and via the C-alpha of the other amino acid residue in said at least two amino acid residues.
A polymer having the formula C12K(NC8K)11NH2 (SEQ ID NO:
Dependencies are inferred from the claim text.