Back to results
US 2012/0237560 A1Published application
Cardiac Compositions
AssigneeThe Regents of the University of California
InventorsB. Chia Soo, Kang Ting, Bruno Peault
Life of this patent
Estimating the term…
Abstract
Embodiments of the present invention provide a composition comprising perivascular stem cells or induced pluripotent cells (iPS) and a NELL-1 factor for cardiac or vascular regeneration and methods of making and using the same.
Claims24
A composition, comprising:
- a population of perivascular stem cells (PSCs) or induced pluripotent stem cells, and
- a cardioinductive agent,
- wherein the cardioinductive agent is in:
- a therapeutically effective amount for causing PSC or iPS to differentiate in the cardiac cell or progenitor lineages so as to generate cardio tissues;
- or
- a therapeutically effective amount for enhancing the survivability or engraftment of the PSC or iPS where PSC or iPS provide trophic factors or enhance vascular ingrowth.
3 more elements
An implantable device, comprising:
- a population of perivascular stem cells (PSCs) or induced pluripotent stem cells, and
- a cardioinductive agent,
- wherein the cardioinductive agent is in:
- a therapeutically effective amount for causing PSC or iPS to differentiate in the cardiac cell or progenitor lineages so as to generate cardio tissues;
- or
- a therapeutically effective amount for enhancing the survivability or engraftment of the PSC or iPS where PSC or iPS provide trophic factors or enhance vascular ingrowth.
3 more elements
A method of fabricating a composition or implantable device, comprising:
- providing a population of perivascular stem cells (PSC) or induced pluripotent stem cells (iPS),
- providing a cardioinductive agent, and
- forming the composition or implantable device,
- wherein the cardioinductive agent is in:
- a therapeutically effective amount for causing PSC or iPS to differentiate in the cardiac cell or progenitor lineages so as to generate cardio tissues;
- or
- a therapeutically effective amount for enhancing the survivability or engraftment of the PSC or iPS where PSC or iPS provide trophic factors or enhance vascular ingrowth.
4 more elements
A method of treating or ameliorating a cardiac condition, comprising administering to a subject a composition in need thereof, the composition comprising:
- a population of perivascular stem cells (PSC) or induced pluripotent stem cells (iPS),
- a cardioinductive agent,
- wherein the cardioinductive agent is in:
- a therapeutically effective amount for causing PSC or iPS to differentiate in the cardiac cell or progenitor lineages so as to generate cardio tissues;
- or
- a therapeutically effective amount for enhancing the survivability or engraftment of the PSC or iPS where PSC or iPS provide trophic factors or enhance vascular ingrowth.
3 more elements
Dependencies are inferred from the claim text.