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AssigneeSiemens Healthcare Diagnostics Inc.
InventorsTie Q. Wei, Alan R. Craig, Fiore M. Celano, III, Samantha Janas
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Methods and reagents are disclosed for maintaining the antibody-binding activity of a conjugate of an immunosuppressant drug and a conjugative moiety. The method comprises combining with the conjugate an effective amount of a chelating agent. Compositions include in an aqueous medium (i) a conjugate of an immunosuppressant drug and a conjugative moiety and (ii) a chelating agent in an amount effective to maintain an antibody-binding activity of the conjugate of the immunosuppressant drug and the conjugative moiety. The compositions may be employed in assays for the determination of analytes that include immunosuppressant drug analytes and antibodies for an immunosuppressant drug.
A method of maintaining the antibody-binding activity of a conjugate of an immunosuppressant drug and a conjugative moiety, said method comprising combining the conjugate and an effective amount of a chelating agent.
A method of maintaining the antibody-binding activity of a conjugate of sirolimus and a conjugative moiety, said method comprising combining with said conjugate an effective amount of a chelating agent.
A composition comprising in an aqueous medium (i) a conjugate of an immunosuppressant drug and a conjugative moiety and (ii) a chelating agent in an amount effective to maintain an antibody-binding activity of the conjugate of the immunosuppressant drug and the conjugative moiety.
A composition comprising in an aqueous medium (i) a conjugate of sirolimus and a conjugative moiety and (ii) an ethylene diamine tetraacetic acid reagent in an amount effective to maintain an antibody-binding activity of the conjugate of the sirolimus and the conjugative moiety.
Dependencies are inferred from the claim text.