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US 2012/0237545 A1Published application
Assays for influenza virus hemagglutinins
AssigneeNorvartis AG
InventorsPhilip Dormitzer, Yingxia Wen, Paola Rinella, Gene Palmer
Life of this patent
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Abstract
A combination of ultrafiltration and HPLC is used to analyze influenza virus. This combination is able to quantify hemagglutinin (HA) and correlates well with single radial immunodiffusion (SRID) results, but can be performed without the delay of waiting for immunochemical SRID reagents.
Claims24
A method for purifying influenza virus HA in a sample, comprising steps of:
- (i) ultrafiltration of the sample to provide a filtrate;
- and (ii) RP-HPLC of the filtrate to separate any HA therein from any other components therein.
The method of any 1, wherein the sample is a bulk vaccine.
Dependencies are inferred from the claim text.