Method for making targeted therapeutic agents directed to soluble targets
AssigneeProteoNova, Inc.
InventorsRichard B. WILLIAMS, Robert GUERRERO
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Abstract
Provided herein are methods for making targeted therapeutics that target soluble agents such as toxins, venoms, and factors that alter physiological biopathways as well as methods of using such therapeutics to treat patients or patient populations to reduce, eliminate, or inactivate, detrimental soluble agents that such patients or patient populations have been exposed to. In several embodiments the targeted therapeutics comprise a portion that interacts with a soluble agent of interest and a second portion that interacts with a subject's immune system, which enables treatment of a patient for exposure to the soluble agent.
Claims20
A method for generation of a bifunctional targeted therapeutic that targets a soluble agent, the method comprising:
- identifying a first protein capable of interacting with a desired soluble target;
- identifying a first mRNA that encodes for said first protein;
- identifying an antigen capable of eliciting an immune response through interaction with one or more components of the immune system;
- identifying a second mRNA that encodes for said antigen;
- generating a first and a second cDNA corresponding to each of said first and said second mRNAs;
- fusing said first and said cDNA to generate a fused cDNA;
- translating said fused cDNA into a corresponding fused protein,
- wherein said a first portion of said fused protein is capable of interacting with said desired soluble target and a second portion of said fused protein is capable of eliciting an immune response,
- thereby generating a bifunctional targeted therapeutic that targets a soluble agent.
Dependencies are inferred from the claim text.