RECOMBINANTLY EXPRESSED PLASMODIUM CelTOS ANTIGEN AND METHODS OF USE THEREOF
AssigneeThe United States of America as Represented by the Secratary of the Army
InventorsEvelina Angov, Elke Bergmann-Leitner, Christian Ockenhouse
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Abstract
A synthetic nucleotide, which transcribes as the cell-traversal protein for ookinetes and sporozoites (CelTOS) antigen of Malaria Plasmodium, and methods of use thereof.
Claims26
A synthetic nucleotide, which transcribes as an antigen of Malaria Plasmodium and comprises of nucleotide sequence SEQ ID NO:1 or a substantially homologous sequence thereof.
A synthetic nucleotide, which transcribes as an antigen of Malaria Plasmodium and comprises of nucleotide sequence SEQ ID NO:4 as modified for codon harmonization or a substantially homologous sequence thereof.
A synthetic polypeptide, which acts as an antigen of Malaria Plasmodium and comprises of amino acid sequence SEQ ID NO:2 or a substantially homologous sequence thereof.
A synthetic polypeptide translated from a codon harmonized, wild-type nucleotide sequence that transcribes as Malaria Plasmodium CelTOS protein.
Dependencies are inferred from the claim text.