Methods for producing an immune response to tuberculosis
AssigneesOregon Health & Science University, The United States of America as represented by the Department of Veteran Affairs
InventorsDavid M. Lewinsohn, Deborah A. Lewinsohn
Life of this patent
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Abstract
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for inhibiting an infection with Mtb, preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for the inhibition, prevention and/or treatment of tuberculosis are also disclosed.
Claims31
1-10. (canceled)
An isolated polypeptide comprising nine to twenty consecutive amino acids of at least one of the amino acid sequences set forth as SEQ ID NOs:
- 1-16, wherein the nine to twenty consecutive amino acids specifically bind major histocompatibility complex (MHC) class I, wherein the isolated polypeptide does not comprise any of the amino acid sequences set forth as SEQ ID NOs:
- 1-16.
18-20. (canceled)
26-31. (canceled)
A method for producing an immune response to Mycobacterium tuberculosis (Mtb) in a subject, comprising
- administering to the subject a therapeutically effective amount of a polypeptide, or a polynucleotide encoding the polypeptide, wherein the polypeptide comprises:
- (a) at least one of the amino acid sequences set forth as SEQ ID NO:
- 6, SEQ ID NO:
- 2, SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16;
- or
- (b) at least nine to twenty consecutive amino acids of at least one of the amino acid sequences set forth as SEQ ID NO:
- 6, SEQ ID NO:
- 2, SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16, wherein the nine to twenty consecutive amino acids specifically bind major histocompatibility complex (MHC) class I;
- thereby inducing an immune response to Mycobacterium tuberculosis.
(canceled)
(canceled)
40-41. (canceled)
A method for treating a subject infected with Mycobacterium tuberculosis, comprising administering to the subject a therapeutically effective amount of a polypeptide, or a polynucleotide encoding the polypeptide, wherein the polypeptide comprises:
- (a) at least one of the amino acid sequences set forth as SEQ ID NO:
- 6, SEQ ID NO:
- 2, SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16;
- or
- (b) at least nine to twenty consecutive amino acids of at least one of the amino acid sequences set forth as SEQ ID NO:
- 6, SEQ ID NO:
- 2, SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16, wherein the nine to twenty consecutive amino acids specifically bind major histocompatibility complex (MHC) class I;
- thereby treating the subject infected with Mycobacterium tuberculosis.
A method of inhibiting an infection with Mycobacterium tuberculosis in a subject, comprising administering to the subject a therapeutically effective amount of a polypeptide, or a polynucleotide encoding the polypeptide, wherein the polypeptide comprises:
- (a) at least one of the amino acid sequences set forth as SEQ ID NO:
- 6, SEQ ID NO:
- 2, SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16;
- or
- (b) at least nine to twenty consecutive amino acids of at least one of the amino acid sequences set forth as SEQ ID NO:
- 6, SEQ ID NO:
- 2, SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16, wherein the nine to twenty consecutive amino acids specifically bind major histocompatibility complex (MHC) class I;
- thereby inhibiting the infection with Mycobacterium tuberculosis in the subject.
Dependencies are inferred from the claim text.