Therapeutic Compositions For The Treatment of HPV-Induced Diseases
AssigneeProyecto De Biomedicina Cima, S.L.
InventorsPedro Berraondo-Lopez, Juan Jose Lasarte Sagastibelza, Christina Mansilla Puerta, Jesus Maria Prieto Valtuena, Pablo Sarobe Ugarriza
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Abstract
The invention relates to immunogenic conjugates comprising an immunogenic region of human papilloma virus E7 protein and the fibronectin EDA region, as well to compositions comprising said conjugates and to dendritic cells obtained by stimulation with said conjugates and compositions. Moreover, the invention relates to methods for the treatment of diseases caused by the human papilloma virus (HPV) using said conjugates, compositions and dendritic cells.
Claims28
A conjugate comprising:
- i) the fibronectin EDA region or a functionally equivalent variant thereof and
- ii) at least one HPV E7-derived antigenic peptide,
- wherein components (i) and (ii) are covalently coupled and wherein the conjugate promotes a cytotoxic response towards the antigenic peptide or peptides.
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Dependencies are inferred from the claim text.