Compositions and Methods for Inducing Apoptosis in Prostate Cancer Cells
OwnerGeorge Kulik, Mark E. Welker +1inventors
InventorsGeorge Kulik, Mark E. Welker, Freddie R. Salsbury, JR.
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Abstract
Compositions and methods for inhibiting the growth of cancer cells, particularly prostate cancer cells are disclosed.
Claims17
A method for synergistically inducing apoptosis in cancer cells in a patient in need thereof comprising administering an effective amount of a PI3K inhibitor and a toxin molecule, in a pharmaceutically acceptable carrier, said PI3K inhibitor and toxin molecule acting synergistically to rapidly induce apoptosis in said cancer cell, said method optionally comprising administration of a chemotherapeutic agent.
A synergistic anti-prostate cancer formulation comprising:
- i) a LY294002 prodrug or ZSTK474 prodrug operably linked to a PSA cleavable linker which is effective to inhibit PI3K activity;
- ii) a Pseudomonas exotoxin (PE) A or PE40 operably linked to an antibody which has binding specificity for PMSA antigen thereby forming an immunotoxin, said immunotoxin optionally comprising a PSA cleavable linker, each of i) and
- ii) being present in a pharmaceutically acceptable carrier.
A synergistic anti-prostate cancer formulation comprising:
- i) ZSTK474 operably linked to a PSA cleavable linker and
- ii) Pseudomonas exotoxin (PE) A operably linked to J591, each of i) and ii) being present in a pharmaceutically acceptable carrier.
A synergistic anti-prostate cancer formulation comprising:
- i) LY294002 operably linked to a PSA cleavable linker and
- ii) Pseudomonas exotoxin (PE) A operably linked to J591, each of i) and ii) being present in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.