Boris isoforms and methods of detecting and treating disease
AssigneesServices, The United States of America, as represented by the Secretary, Department of Health and Human
InventorsVictor V. Lobanenkov, Elena Pugacheva, Dmitri Loukinov
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Abstract
A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.
Claims20
-48. (canceled)
An isolated or purified polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 26-42.
A kit for the detection of BORIS expression in a mammal, which kit comprises
- (a) a probe set comprising one or more probes that bind to (i) a BORIS isoform polypeptide, or (ii) an auto-antibody to a BORIS isoform polypeptide, wherein the BORIS isoform polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 26-42, and
- (b) a reagent that facilitates the detection of the probe.
Dependencies are inferred from the claim text.