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US 2012/0237491 A1Published application
Phage derived antimicrobial activities
AssigneeGangaGen, Inc.
InventorsSriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
Life of this patent
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Abstract
The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
Claims17
1-44. (canceled)
A chimeric polypeptide comprising
- (i) a muralytic domain (MD) of a Tail Associated Muralytic Enzyme (TAME) polypeptide, and
- (ii) a heterologous cell binding domain (CBD) that binds to a target bacterium,
- wherein the target bacterium exhibits reduced or no growth after being contacted with the chimeric polypeptide.
Dependencies are inferred from the claim text.