Trabecular Meshwork Stem Cells
OwnerYiqin Du, James L. Funderburgh +1inventors
InventorsYiqin Du, James L. Funderburgh, Joel Steven Schuman
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Abstract
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and isolated populations of TM cells obtained therefrom. Compositions, kits, and devices comprising the isolated populations of multipotent stem cells or TM cells are also provided herein. Further provided are methods of using the compositions, kits, and devices for decreasing intraocular pressure in an eye, increasing cell density in a trabecular meshwork of an eye, increasing outflow of aqueous humor from an eye, or treating or preventing a medical condition in a subject.
Claims44
An isolated population of multipotent stem cells which are capable of differentiating into trabecular meshwork (TM) cells.
A method of obtaining an isolated population of TM cells, comprising obtaining an isolated population of multipotent stem cells and culturing the isolated population of multipotent stem cells in a medium comprising factors present in fetal bovine serum, aqueous humor, or in both fetal bovine serum and aqueous humor, to induce differentiation of the multipotent stem cells into TM cells.
Dependencies are inferred from the claim text.