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US 2012/0237484 A1Published application
Generation of Functional Basal Forebrain Cholinergic Neurons From Stem Cells
AssigneeNorthwestern University
InventorsChristopher Bissonnette, John Kessler
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Abstract
The present invention provides method, compositions, and systems for generating basal forebrain cholinergic neurons (BFCNs) using FGF8, SHH, LXH8, GBX1, or vectors encoding these ligands, as well as using such BFCNs to treat neurological disorders such as Alzheimer's disease.
Claims20
A method of generating basal forebrain cholinergic neurons (BFCNs) comprising:
- treating neural progenitor cells with at least one ligand, or an expression vector encoding said ligand, wherein said ligand is selected from the group consisting of:
- FGF8, a biologically active fragment or variant of FGF8;
- sonic hedgehog (SHH), or a biologically active fragment or variant of SHH;
- LHX8, or a biologically active fragment or variant of LHX8;
- and GBX1, or a biologically active fragment or variant of GBX1;
- wherein said treating generates BFCNs.
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A method of treating a patient with a neurological disorder comprising:
- implanting an isolated population of BFCN's into the brain area of a patient with a neurological disorder.
A system comprising:
- a) neural progenitor cells, and
- b) at least one ligand, or at least one expression vector encoding said ligand, wherein said ligand is selected from the group consisting of:
- FGF8, a biologically active fragment or variant of FGF8;
- sonic hedgehog (SHH), or a biologically active fragment or variant of SHH;
- LHX8, or a biologically active fragment or variant of LHX8;
- and GBX1, or a biologically active fragment or variant of GBX1.
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Dependencies are inferred from the claim text.