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US 2012/0237481 A1Published application
Incorporation of the B18R gene to enhance antitumor effect of virotherapy
OwnerXiaoliu Zhang, Xinping Fuinventors
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Abstract
The present invention relates to a novel composition and method to potentiate the antitumor effect of an oncolytic virus by providing for resistance against a host's innate interferon response. Particularly, a B18R gene is incorporated into an oncolytic virus. During treatment of a host with the modified oncolytic virus, the oncolytic virus retains its phenotype, and the host's innate immune response has a minimal affect on viral replication.
Claims34
A method of treating cancer, comprising:
- administering to a host a medicament including an oncolytic virus, wherein the oncolytic virus is modified by the incorporation of a B18R gene.
A method of generating an oncolytic virus, comprising:
- incorporating a B18R gene into the oncolytic virus.
An oncolytic virus, comprising:
- a B18R gene incorporated into the oncolytic virus.
Dependencies are inferred from the claim text.