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US 2012/0237478 A1Published application
Modulators of pharmacokinetic properties of therapeutics
AssigneeGilead Sciences, Inc.
InventorsManoj C. Desai, Allen Y. Hong, Hon C. Hui, Hongtao Liu, Randall W. Vivian, Lianhong Xu
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Abstract
The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Claims10
1-41. (canceled)
A method for treating an HCV infection in a patient in need thereof, comprising administering to the patient an amount of a compound
- or a pharmaceutically acceptable salt-thereof, which is effective to inhibit cytochrome P450 monoxygenase in the patient, in combination with a therapeutically effective amount of one or more therapeutic agents which are metabolized by cytochrome P450 monoxygenase and are selected from the group consisting of interferons, ribavirin, taribavirin, NS3 protease inhibitors, alpha-glucosidase 1 inhibitors, hepatoprotectants, non-nucleoside inhibitors, other drugs for treating HCV, and mixtures thereof.
Dependencies are inferred from the claim text.