Pharmaceutical Compositions for Sustained Release Delivery of Peptides
AssigneeForessee Pharmaceuticals, LLC
InventorsYuhua LI, Benjamin CHIEN
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Abstract
The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
Claims21
1-46. (canceled)
A liquid polymeric pharmaceutical composition for controlled release of a therapeutic polypeptide, comprising effective amounts of:
- (a) a pharmaceutically acceptable, water insoluble, biodegradable polymer;
- (b) a pharmaceutically acceptable organic solvent which solubilizes the biodegradable polymer;
- and (c) a therapeutic polypeptide conjugated with one or more amphiphilic moieties, wherein the composition is in the form of an injectable viscous liquid and is capable of forming a controlled release implant by dissipation or dispersion of the organic solvent within a subject's body;
- and wherein the composition has a higher in vitro stability and a lower initial burst release than the composition would were the therapeutic polypeptide not conjugated to the amphiphilic moieties.
Dependencies are inferred from the claim text.