Amido-amine polymer compositions
AssigneeGenzyme Corporation
InventorsPradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval
Life of this patent
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Abstract
Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.
Claims16
1-43. (canceled)
A method of removing a compound or ion from the gastrointestinal tract of an animal comprising administering an effective amount of a pharmaceutical composition comprising:
- a) a copolymer derived from compounds according to the following Formulas I and II:
- wherein R1 independently represents a hydrogen radical. —RNH2, —R—N—(R—NH2)2 or —R—N—(R—N—(R—NH2)2)2, wherein R independently represents a branched or unbranched, substituted or unsubstituted alkyl radical, with the proviso that at least one R1 is not a hydrogen radical;
- R2 independently represents a hydrogen radical or a branched or unbranched, substituted or unsubstituted alkyl radical;
- and
- b) a pharmaceutically acceptable excipient.
A method of removing a compound or ion from the gastrointestinal tract of an animal comprising administering an effective amount of a pharmaceutical composition comprising:
- a) a hyperbranched copolymer derived from:
- (i) a multi-amine monomer;
- and
- (ii) a multifunctional monomer comprising two or more amine-reactive groups;
- and
- b) a pharmaceutically acceptable excipient.
A method of removing a compound or ion from the gastrointestinal tract of an animal comprising administering a pharmaceutical composition comprising:
- a) a copolymer comprising
- i) at least one multi-amine or residue thereof;
- and
- ii) at least one ester or multi-ester or residue thereof;
- wherein said copolymer has a degree of branching of from 0.10 to 0.95;
- and
- b) a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.