# US 2012/0237456 A1 · Oral compositions containing extracts of garcinia mangostana l. and related methods

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- Number: US 2012/0237456 A1
- Document ID: US20120237456A1
- Status: Published application
- Kind: A1
- Application number: 13/513,606
- Filed: 2010-12-01
- Published: 2012-09-20
- Earliest claimed: 2009-12-04
- Assignees: Colgate-Palmolive Company
- Inventors: Harsh M. Trivedi; Elizabeth K. Gittins
- Web page: https://patentgrep.com/patent/US20120237456A1

## CPC

- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/9794: Liliopsida [monocotyledons]
- A61K 36/00: Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines {(antigens from pollen A61K39/36)}
- A61K 36/38: Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Described herein are compositions comprising a combination of extracts, and methods of preparing and using the same.

## Claims

### Claim 1

An oral composition comprising:
a combination of extracts comprising an extract from Garcinia mangostana L. and a natural extract other than the extract from Garcinia mangostana L.; and
an orally acceptable carrier, wherein the composition comprises 0.01% to 5% by weight of the combination of extracts.

### Claim 2 (depends on 1)

A composition according to claim 1, comprising 0.1% to 2% by weight of the combination of extracts.

### Claim 3 (depends on 1)

A composition according to claim 1, wherein the natural extract other than the extract from Garcinia mangostana L. is one or more natural extracts selected from the group consisting of extracts of oregano, magnolia, cranberry, rosemary, Camellia, morin, zingiber officinale, Myristica fragrans, Punica granatum, Zizyphus Joazeiro, Jabara, Azadirachta indica, Acacia, Oolong tea, Juglans regia, Zanthoxylum alantum, Mimusops elengi, Hibiscus abelmoschus, Ayurvedic, Carapa procera, Khaya senegalensis, Salvadora persica, Cucurbitaceae (Citrullus colocynthis), Acacia catechu, Acacia nilotica, Achyrathes aspera, Azadirachta indica, Aristolochia bracteolate, Cinnamomum camphora, Cinnamomum verum, Curcuma longa, Eucalyptus globulus, Ficus bengalensis, Juglans regia, Madhuca longifolia, Mimusops elengi, Ocimum sanctum, Oolonga tea, Piper betel leaves, Piper longum, Piper nigrum, Potentilla fulgens, Syzygium aromaticum, Spilanthes calva, Vaccinium macrocarpon, Zanthoxylum armatum, and mixtures thereof.

### Claim 4 (depends on 1)

A composition according to claim 1, further comprising an additional antibacterial agent selected from: phenolic compounds, stannous ions, zinc ions, and mixtures thereof.

### Claim 5 (depends on 4)

A composition according to claim 4, wherein the zinc ions are provided by one or more zinc-containing compounds selected from the group consisting of zinc acetate, zinc citrate, zinc gluconate, zinc glycinate, zinc oxide, zinc sulfate, sodium zinc citrate, and mixtures thereof.

### Claim 6 (depends on 1)

A composition according to claim 1, wherein the composition further comprises at least one additional component selected from the group consisting of humectants, abrasives, anticaries agents, anticalculus or tartar control agents, anionic carboxylate polymers, viscosity modifiers, surfactants, flavorants, pigments, and mixtures thereof.

### Claim 7 (depends on 1)

A composition according to claim 1, wherein the composition is a dentifrice in a form selected from the group consisting of: powder; toothpaste or dental gel; a periodontal gel; a liquid suitable for painting a dental surface; a chewing gum; a dissolvable, partially dissolvable or non-dissolvable film or strip; a bead, a wafer; a wipe or towelette; an implant; a mouthrinse, a foam, and dental floss.

### Claim 8 (depends on 1)

A method of treating a disease or condition of oral cavity soft tissue comprising administering to the oral cavity of a patient in need thereof, a composition according to claim 1.

### Claim 9 (depends on 8)

The method according to claim 8, wherein the disease or condition is xerostomia.

### Claim 10 (depends on 1)

A composition according to claim 1 for use in the treatment of xerostomia.