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US 2012/0237446 A1Published application
Compounds for binding and imaging amyloid plaques and their use
AssigneeBayer Pharma Aktiengesellschaft
InventorsUlrike Röhn, Hermann Künzer, Tobias Heinrich, Markus Berger, Damian Brockschnieder, Sabine Krause, Thomas Dyrks, Andrea Thiele, Ursula Mönning, Ulf Bömer
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Abstract
The present invention relates to novel compounds (3-aminopropen-1-ones) useful for binding and imaging beta amyloid deposits and their use in detecting or treating Alzheimer's disease and amyloidosis.
Claims5
A Compound of formula I
- for use as diagnostic agent or imaging agent for imaging diseases associated with beta amyloid deposits
- wherein
- R1 is H, phenyl or X;
- R2 is H, OCH3, N(CH3)2, O—(CH2)n—X;
- (CH2)n—X or X;
- R3 is H;
- R4 is H or Br;
- X is F or 18F;
- Y is CH, CCN, CCF3 or N;
- and
- n is 1, 2 or 3;
- with the proviso that one of the substituents R1 and R2 comprises 18F or is 18F,
- or an isomeric form of said compound;
- and pharmaceutically acceptable salts and salt complexes thereof.
11 more elements
Dependencies are inferred from the claim text.