Drug activation system
AssigneeBangor University
InventorsChristopher Gwenin, Maher Kalaji, Vanessa Roberts
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Abstract
The present invention discloses a drug activator carrier comprising: a) particles having a metallic or metallic oxide core prepared from a paramagnetic material, said metallic core being coated with a coating material selected from polymer, metal or metal oxide; b) a biological material, having reductase activity, bound onto the metal coating the particles of step a), and wherein said biological material is capable of activating non-toxic pro-drugs into active and toxic drugs suitable for treating a disease; said drug activator carrier allowing targeted delivery of the toxic drug.
Claims19
A drug activator carrier comprising:
- a) particles having a metallic or metallic oxide core prepared from a paramagnetic material, said metallic core being coated with a coating material selected from polymer, metal or metal oxide;
- b) a biological material, having reductase activity, bound onto the coating material coating the particles of step a), and wherein said biological material is capable of activating non-toxic pro-drugs into active and toxic drugs suitable for treating a disease;
- wherein said drug activator carrier allows targeted delivery of the toxic drug.
A method for preparing a drug activating carrier that comprises the steps of:
- a) providing nanoparticles of a paramagnetic material;
- b) coating said particles with a metal or metal oxide or polymer;
- c) immobilising an enzyme capable of transforming a non toxic prodrug into an active and toxic drug for treating a disease, by chemical bonding between the enzyme and the coating.
Dependencies are inferred from the claim text.