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US 2012/0232298 A1Published application
Compounds for preparing immunological adjuvant
AssigneeEisai R&D Management Co., Ltd.
InventorsFrancis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
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Abstract
The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
Claims8
-24. (canceled)
A compound of formula (17):
- wherein:
- R is hydrogen or a C1-C6 alkyl group;
- one of R2a and R2b is H and the other is a monovalent nitrogen protecting group, or R2a and R2b taken together are a divalent nitrogen protecting group;
- R4 is a C5-C12 alkyl group or a C5-C12 alkenyl group;
- and
- R5 is a C5-C15 alkyl group or a C5-C15 alkenyl group.
3 more elements
-34. (canceled)
Dependencies are inferred from the claim text.