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US 2012/0232290 A1Published application
Reactivity of hydroxymethylglutaryl coenzyme a (hmg-coa) reductase inhibitors containing conjugated dienes with phenolic antioxidants in the solid-state
OwnerRussell F. Langinventor
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Abstract
The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant that provided the best stability for the statin. Phenolic antioxidants were evaluated.
Claims3
The use of butylated hydroxy anisole (BHA) to reduce oxidative degradation of simvastatin.
The use of propyl gallate to reduce oxidative degradation of simvastatin.
The use of α-tocopherol to reduce oxidative degradation of simvastatin.
Dependencies are inferred from the claim text.