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US 2012/0232280 A1Published application
DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALKANONE AND USE THEREOF AS p75 INHIBITORS
AssigneeSanofi-Aventis
InventorsMarco BARONI, Françoise BONO, Sandrine DELBARY-GOSSART
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Abstract
The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): in which the variables are as defined herein, to the preparation thereof and to the therapeutic use thereof.
Claims6
A compound of Formula (II):
- in which:
- m represents 0 or 1;
- A represents:
- and B represents a hydrogen atom
- or
- A represents a hydrogen atom and B represents:
- n represents 1 or 2;
- R1 represents a halogen atom, a (C1-C4)alkyl group, a trifluoromethyl group, a (C1-C4)alkoxy group or a trifluoromethoxy group;
- R2 represents a hydrogen atom, a halogen atom, a (C1-C4)alkyl group, a trifluoromethyl group, a (C1-C4)alkoxy group, a trifluoromethoxy group, a COOR group or a CON H2 group;
- and Hal represents a halogen atom;
- with the exception of 2-chloro-1-[4-(2-methoxyphenyl)-3,6-dihydro-2H-pyridin-1-yl]ethanone and of 2-chloro-1-[4-(4-bromophenyl)-3,6-dihydro-2H-pyridin-1-yl]ethanone;
- in the form of a base or of a pharmaceutically acceptable addition salt with an acid.
9 more elements
Dependencies are inferred from the claim text.