Process for preparing montelukast and salts thereof
AssigneeLaurus Labs Private Limited
InventorsVenkata Sunil Kumar INDUKURI, Srinivas SIMHADRI, Satyanarayana CHAVA
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Abstract
A method for the preparation of montelukast and salts thereof has been described. The method comprises of following steps: (a) (S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyliphenyl)-3-(2-isopropenylphenyljpropyl methane sulphonate (styrene mesylate salt) (b) coupling with 1-(mercapto methyl)cyclopropane acetic acid followed by salification with an amine gives styrene amine salt (c) Converting styrene amine salt to Montelukast amine salt (d) Converting Montelukast amine salt to Montelukast free acid and or its required alkali/alkaline salt.
Claims23
1-15. (canceled)
A process for preparation of Montelukast or a salt thereof, said process comprising the steps of:
- condensing styrene mesylate of formula (V)
- with 1-(mercapto methyl) cyclopropane acetic acid with an amine to obtain (1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanyl methyl]cyclopropyl]acetic acid styrene amine salt;
- converting the styrene amine salt to Montelukast amine salt;
- and
- converting the Montelukast amine salt to Montelukast free acid or an alkali or alkaline salt of Montelukast.
A 1-methyl-3-phenylpropylamine salt of Montelukast.
A composition containing Montelukast 1-methyl-3-phenylpropylamine salt.
A method for making 1-methyl-3-phenylpropylamine salt of Montelukast comprising the steps of
- condensing styrene mesylate of formula (V)
- with 1-(mercapto methyl)cyclopropane acetic acid and 1-methyl-3-phenylpropylamine to obtain (1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanyl methyl]cyclopropyl]acetic acid styrene 1-methyl-3-phenylpropylamine salt;
- treating the styrene 1-methyl-3-phenylpropylamine salt with sulfuric acid to produce Montelukast 1-methyl-3-phenylpropylamine salt.
Dependencies are inferred from the claim text.