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US 2012/0232275 A1Published application
Process for preparing 5-fluoro-1h-pyrazolo [3,4-b] pyridin-3-amine and derivatives thereof
AssigneeVertex Pharmaceuticals Incorporated
InventorsJuan-Miguel Jimenez, Philip Collier, Jeremy Green, Andrew Miller, Huai Gao, Sylvain Loic Jean-Luc Hamon, Albert Cornelis Dros
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Abstract
The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
Claims17
A process for preparing a compound of formula 5:
- comprising the step of selectively de-chlorinating a compound of formula 1:
- under suitable de-chlorination conditions to form a compound of formula 2:
17-41. (canceled)
Dependencies are inferred from the claim text.