Dipeptide Mimics, Libraries Combining Two Dipeptide Mimics with a Third Group, and Methods for Production Thereof
AssigneeGradalis, Inc.
InventorKevin Burgess
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Abstract
Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety bound to said core molecule. Monovalent compounds also comprise a macrocyclic ring, a nucleophilic moiety, and a spacer group. Monovalent compounds may be combined into bivalent and trivalent compounds, some of which may have a labeling tag. Methods of production of bivalent compounds and contemplated uses thereof are disclosed.
Claims7
1-38. (canceled)
A dipeptide mimic compound to mimic proteins in a protein-protein interactions having the structure
- wherein R0 is an alkene, alkane, alkyne, arylene, heteroarylene, heterocyclene, a nucleophilic moiety, a polymer, an N group, a C group, an O group, a H group a fluorescein tag, a biotin tag or a combination thereof;
- and
- R1, R2, R1′, and R2′ groups that independently comprise an CH3—, HN═C(NH2)—NH—(CH2)3—, H2N—CO—CH2—, HOOC—CH2—, HS—CH2—, HOOC—(CH2)2—, H2N—CO—(CH2)2—, NH2—CH2—COOH, NH—CH═N—CH═C—CH2—, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, CH3—S—(CH2)2—, Ph-CH2—, NH—(CH2)3—CH—COOH, HO—CH2—, CH3—CH(OH)—, Ph-NH—CH═C—CH2—, HO-Ph-CH2—, or (CH3)2—CH—.
A dipeptide mimic compound having the structure:
- wherein core molecule X1 is selected from alkenes, alkanes, alkynes, arylenes, heteroarylenes, heterocyclenes, polymers and derivatives thereof;
- spacer K1 and spacer K2 are independently selected from alkanes, alkenes, alkynes, cycloalkanes, heterocycloalkanes, heteroarylenes, arylenes and heterocyclenes and any analog thereof or combination thereof;
- mimic backbone Y1 and mimic backbone Y2 independently comprise alkanes, alkenes, alkynes, cycloalkanes, heterocycloalkanes, heteroarylenes, arylenes and heterocyclenes and any analog thereof, a N group, an O group, a H or combination thereof;
- and
- R1, R2, R1′, and R2′ groups independently comprise a side chain residue extending from the mimic backbone.
A protein mimic compound having the structure:
- wherein core molecule X1 is selected from alkenes, alkanes, alkynes, arylenes, heteroarylenes, heterocyclenes, polymers and derivatives thereof;
- mimic backbone Y1 comprising a spacer comprising a piperidine or a piperazine connected to a first mimic backbone comprising R1 and R2 side groups mimic backbone Y2 comprising a spacer comprising a piperidine or a piperazine connected to a second mimic backbone comprising R1′ and R2′ side groups.
Dependencies are inferred from the claim text.