1,2-Disubstituted Heterocyclic Compounds

A compound of Formula (I) or (II) or (III) or pharmaceutically acceptable salt thereof

• Wherein:
• HET is a heterocyclic ring selected from Formulas A1-A26 and A29-42 below
• and the left most radical is connected to the X group;
• W is selected from halogen, cyano, nitro, alkoxy, amino, alkylamino, dialkylamino, carboxy, amido, alkylamido, and dialkylamido;
• X is selected from C3-C8 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C7 cycloalkylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl and optionally substituted heteroarylalkyl;
• Y is a bond or a divalent linker group selected from —CH2—, —O—, —SO2—, —CH2O—, —OCH2— and —CH2CH2— with the rightmost radical of the Y group connected to the Z substituent;
• Z is optionally substituted heteroaryl;
• R1a is selected from C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C7 cycloalkylalkyl and optionally substituted C4-C7 alkoxyalkyl;
• R1b is selected from C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C7 cycloalkylalkyl and optionally substituted C4-C7 alkoxyalkyl;
• Each R2 is independently selected from C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C7 cycloalkylalkyl and optionally substituted C4-C7 alkoxyalkyl, or two R2 groups taken together form a 3-6 membered cycloalkyl ring;
• R3 and R4 are independently selected from C1-C4 alkyl, CF3, optionally substituted C3-C6 cycloalkyl, or R3 and R4 taken together form a 3-6 membered cycloalkyl ring;
• R5 is selected from C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C7 cycloalkylalkyl and optionally substituted C4-C7 alkoxyalkyl;
• R6 is selected from hydrogen, C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl and optionally substituted C3-C6 cycloalkylalkyl;
• R7 is selected from hydrogen, C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C7 cycloalkylalkyl and optionally substituted C4-C7 alkoxyalkyl;
• n is independently selected from 1 and 2.