Method for producing a radioactively marked peptide
OwnerMarkus Kinzl, Oliver Lade +1inventors
InventorsMarkus Kinzl, Oliver Lade, Arno Steckenborn
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Abstract
A method for producing a radioactively marked peptide, uses a precursor molecule that is prepared in an organic solvent. A radioactively marked compound having a carboxyl function is added. The carboxyl function is activated, and the activated radioactively marked compound is bonded to the precursor molecule in order to form the radioactively marked peptide. The radioactively marked compound is an isocyanocarboxylic acid. A radioactively marked isocyanocarboxylic acid is used for producing a radioactively marked peptide.
Claims27
1-21. (canceled)
A method for producing a radioactively labeled peptide, comprising:
- providing a precursor molecule which is selected from the group consisting of an amino acid, a peptide and a primary amine, in an organic solvent;
- adding a radioactively labeled compound to the precursor molecule in the organic solvent, the radioactively labeled compound being an isocyanocarboxylic acid, the radioactively labeled compound having a carboxyl function;
- activating the carboxyl function of the radioactively labeled compound to produce an activated radioactively labeled compound;
- and
- linking the activated radioactively labeled compound to the precursor molecule to produce the radioactively labeled peptide.
The use of a radioactively labeled isocyanocarboxylic acid for producing a radioactively labeled peptide.
Dependencies are inferred from the claim text.