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AssigneesNippon Soda Co., Ltd., Hirofumi Takeuchi
InventorsHirofumi Takeuchi, Satoru Abe, Takeshi Shimotori, Gentaro Nemoto
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Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 μm but less than 15 μm are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.
Hydroxyalkylcellulose microparticles, having a volume-average particle size of at least 0.1 μm but less than 15 μm.
A method of producing hydroxyalkylcellulose microparticles, the method comprising generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to a pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution.
A method of producing hydroxyalkylcellulose microparticles, the method comprising supplying a hydroxyalkylcellulose aqueous solution as a raw material to a crushing and drying apparatus, the crushing and drying apparatus comprising a pulse combustor, a raw material supply port positioned close to an outlet of an exhaust pipe of the pulse combustor, and a gas regulation device which sets alterably a particle Reynolds number of an exhaust gas from the pulse combustor that surrounds particles of the supplied raw material to apply continuously generated nonlinear waves to the raw material, thereby crushing and drying the raw material.
Dependencies are inferred from the claim text.