Pharmaceutical combination of prostaglandin compound and nsaid for the treatment of glaucoma and ocular hypertension
AssigneeMicro Labs Limited
InventorsRajesh Kshirsagar, Chandrashekar Kadam, Pravin Kamble, SM Mudda
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Abstract
The present invention relates to a pharmaceutical combination comprising a prostaglandin compound and a NSAID. The present invention particularly relates to an ophthalmic composition comprising travoprost and bromfenac for the treatment of glaucoma and ocular hypertension.
Claims15
A topical pharmaceutical composition comprising:
- a pharmaceutically effective amount of a prostaglandin compound and a pharmaceutically effective amount of a NSAID and one or more pharmaceutically acceptable excipients for the treatment of glaucoma and ocular hypertension.
A topical ophthalmic composition comprising:
- a pharmaceutically effective amount of travoprost or pharmaceutically acceptable salts thereof and a pharmaceutically effective amount of bromfenac or pharmaceutically acceptable salts thereof and one or more pharmaceutically acceptable excipients for the treatment of glaucoma and ocular hypertension.
A topical ophthalmic composition comprising:
- a pharmaceutically effective amount of travoprost or pharmaceutically acceptable salts thereof and a pharmaceutically effective amount of bromfenac or pharmaceutically acceptable salts thereof and polyethoxylated castor oil for the treatment of glaucoma and ocular hypertension.
A topical ophthalmic composition comprising:
- a) Travoprost 0.004% w/v
- b) Bromfenac 0.09% w/v
- c) Polyethoxylated castor oil from about 2% w/v to about 10% w/v
- d) One or more pharmaceutically acceptable excipients.
A process of preparing a topical ophthalmic composition comprising a pharmaceutically effective amount of travoprost or pharmaceutically acceptable salts thereof and a pharmaceutically effective amount of bromfenac or pharmaceutically acceptable salts thereof wherein the process comprises step of adding a chemically-stabilizing amount of a polyethoxylated castor oil to the composition.
Dependencies are inferred from the claim text.