(-)-Epigallocatechin Gallate Derivatives for Inhibiting Proteasome
AssigneesThe Hong Kong Polytechnic University, McGill University, University of South Florida, Wayne State University
InventorsTak-Hang CHAN, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar
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Abstract
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
Claims4
A method of reducing tumor cell growth, the method comprising administering an effective amount of a compound having the formula:
- wherein
- R11, R12, R13, R21, R22, R2, R3, and R4 are each independently selected from the group consisting of —H, and C1 to C10 acyloxyl group;
- and
- R5 is selected from the group consisting of —H, C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl and C3-C7-cycloalkenyl, wherein each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms;
- and
- at least one of R11R12, R13, R21, R22, R2, R3, and R4 is C1 to C10 acyloxyl group.
A method of manufacturing a medicament for reducing tumor cell growth, the method comprising forming a medicament comprising a compound having the formula:
- wherein
- R11, R12, R13, R21, R22, R2, R3, and R4 are each independently selected from the group consisting of —H, and C1 to C10 acyloxyl group;
- and
- R5 is selected from the group consisting of —H, C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C3-C7-cycloalkyl, phenyl, benzyl and C3-C7-cycloalkenyl, wherein each of the last mentioned 7 groups can be substituted with any combination of one to six halogen atoms;
- and
- at least one of R11, R12, R13, R21, R22, R2, R3, and R4 is C1 to C10 acyloxyl group.
A method of reducing tumor cell growth, the method comprising administering an effective amount of a compound having the formula:
- wherein
- R1 is —H;
- R2, R3, and R4 are each independently selected from the group consisting of —H and —OH;
- and
- if R2=R3=R4, then R2 is not —OH.
A method of manufacturing a medicament for reducing tumor cell growth, the method comprising forming a medicament comprising a compound having the formula:
- wherein
- R1 is —H;
- R2, R3, and R4 are each independently selected from the group consisting of —H and —OH;
- and
- if R2=R3=R4, then R2 is not —OH.
Dependencies are inferred from the claim text.