Regulation of neurotransmitter release through anion channels
AssigneeKorea Institute of Science and Technology
InventorsJustin Changjoon LEE, Dong-Ho Woo, Hyung-Ju Park, Hye-Kyung Park
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Abstract
A novel use of anion channels, preferably Ca2+-activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is provided. More specifically, CAAC activity regulators, agents for regulating neurotransmitter release comprising such CAAC activity regulators, and methods of screening agents for regulating neurotransmitter release using CAAC as a target.
Claims15
A method for regulating release of an excitatory neurotransmitter through a Ca2+-activated anion channel (CAAC) from neurons and astrocytes, comprising the step of administering a CAAC activity regulator as an active ingredient to a subject in need thereof.
A method for treating diseases caused by over-release of an excitatory neurotransmitter comprising the step of administering one or more selected from the group consisting of a channel blocking agent against a Ca2+-activated anion channel (CAAC), an antisense RNA against a CAAC-coding nucleotide, and a shRNA against a CAAC-coding nucleotide, as an active ingredient to a subject in need thereof, wherein the diseases caused by over-release of an excitatory neurotransmitter is one or more selected from the group consisting of epileptic seizures, neurotransmitter-induced excitotoxicity, ischemia, brain stroke, brain hemorrhage, epilepsy, traumatic brain injury, and hypoxia.
A method for improving recognition, cognition, movement, memory, or learning capabilities, comprising the step of administering a Ca2+-activated anion channel (CAAC) activator as an active ingredient to a subject in need thereof.
Dependencies are inferred from the claim text.