Modulation of diacylglycerol acyltransferase 1 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBRETT P. MONIA, MARK J. GRAHAM
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Abstract
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 1. Methods of using these compounds for modulation of diacylglycerol acyltransferase 1 expression and for diagnosis and treatment of disease associated with expression of diacylglycerol acyltransferase 1, such as obesity and obesity-related conditions, are provided.
Claims25
A compound comprising a modified oligonucleotide 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding diacylglycerol acyltransferase 1, wherein said compound specifically hybridizes with said nucleic acid molecule (SEQ ID NO:
- 4) encoding diacylglycerol acyltransferase 1 and inhibits the expression of diacylglycerol acyltransferase 1.
(canceled)
19-63. (canceled)
Dependencies are inferred from the claim text.