Amino acid amides of phenoxybutyric acid derivatives

A compound of the formula:

• where X is phenyl substituted at the 3, 4 and 5 positions with R1, R2 or R3 which are selected from hydrogen, chloro, lower alkyl of 1 to 5 carbons, phenoxy, phenyl, naphthyl, or phenyl (lower) alkyl where the lower alkyl group has 1-5 carbon atoms and m is 0 or 1;
• Y is —CONH— or —NHCONH— where the nitrogen atoms are unsubstituted or substituted with other phenoxyisobutyric acid derivatives, or the residue of a phenoxyisobutyric acid and n is 0 or 1;
• Z is unsubstituted phenyl when m is 1 and n is 1;
• when Y is 0, X is 0;
• Z is phenyl substituted at the 3, 4 and 5 positions with R1, R2 or R3 which are selected from hydrogen, chloro, lower alkyl of 1 to 5 carbons, phenoxy, phenyl, naphthyl, or phenyl (lower) alkyl where the lower alkyl group has 1-5 carbon atoms;
• and R4 is hydrogen;
• alkyl of 1-5 carbon atoms;
• aminoalkyl COOR5, where the alkyl group may be substituted with a carboxyl or histidine substituted lower alkyl group having 1-5 carbons and, or is a cycloalkyl group;
• R5 is hydrogen or lower alkyl of 1-5 carbons or an acyl-lower alkyl group where the lower alkyl group has 1-5 carbons.