Non-peptide antagonists of gastrin releasing peptide
AssigneeGovernment of the United States of America, represented by the Secretary, Department of Health
InventorsFrank CUTTITTA, Alfredo MARTINEZ
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Abstract
This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients.
Claims11
A method of improving breathing in a baby, comprising:
- administering to a baby in need of improvement in breathing, an effective amount of a pharmaceutical composition comprising a compound of Formula XIV′, XV′ or XVI′, wherein Formula XIV′ is:
- Formula XV′ is:
- and
- Formula XVI′ is:
- or the corresponding quinone
Dependencies are inferred from the claim text.