Novel sulfonamides as l-cpt1 inhibitors

A compound of formula (I):

• wherein
• A is —C(O)OR1 or selected from the group consisting of tetrazol-5-yl, 5-thioxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl, 2-oxo-2,3-dihydro-[1,2,3,5]oxathiadiazol-4-yl and 5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl;
• X is —N(R5)C(O)— or —C(O)N(R5)—;
• V is N or C(R6);
• Y2 is N or C(R7);
• Y3 is N or C(H);
• Y4 is N or C(R8);
• Z1 is N or C(R9);
• R1 is hydrogen or lower-alkyl;
• R2 is hydrogen, halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy;
• NH2, N(H,lower-alkyl), N(lower-alkyl)2, or lower-alkyl-C(O)—O—, wherein lower-alkyl is optionally substituted with hydroxy, halogen, NH2, N(H,lower-alkyl), N(lower-alkyl)2 or lower-alkoxy;
• R3 is hydrogen, lower-alkyl or lower-alkoxy-lower-alkyl;
• R4 is aryl or heteroaryl, which aryl or heteroaryl is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, lower-alkyl-C(O), lower-alkyl-C(O)—NH, lower-alkyl-C(O)—N(lower-alkyl), lower-alkyl-S(O)2, NH2—S(O)2, N(H,lower-alkyl)-S(O)2 or N(lower-alkyl)2—S(O)2, NH2—C(O), N(H,lower-alkyl)-C(O), N(lower-alkyl)2—C(O), lower-alkoxy-C(O) or heteroaryl which is optionally substituted with lower-alkyl, halogen, thio-lower-alkoxy, or fluoro-lower-alkyl,
• wherein lower-alkyl is optionally substituted with hydroxy, NH2, N(H,lower-alkyl) or N(lower-alkyl)2;
• R5 is hydrogen, lower-alkyl or lower-alkoxy-lower-alkyl;
• R6, R7 and R8 independently from each other are selected from the group consisting of hydrogen, halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy;
• NH2, N(H,lower-alkyl), N(lower-alkyl)2, or lower-alkyl-C(O)—O—, wherein lower-alkyl is optionally substituted with hydroxy, halogen, NH2, N(H,lower-alkyl), N(lower-alkyl)2 and lower-alkoxy;
• R9 is hydrogen, halogen, hydroxy, cyano, lower-alkyl, fluoro-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy;
• NH2, N(H,lower-alkyl), N(lower-alkyl)2, or lower-alkyl-C(O)—O—, wherein lower-alkyl is optionally substituted with hydroxy, halogen, NH2, N(H,lower-alkyl), N(lower-alkyl)2 or lower-alkoxy;
• and pharmaceutically acceptable salts and esters thereof.