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US 2012/0232099 A1Published application
Compounds for the Treatment of Hepatitis C
AssigneeBristol-Myers Squibb Company
InventorsRichard Pracitto, John F. Kadow, John A. Bender, Brett R. Beno, Katherine A. Grant-Young, Ying Han, Piyasena Hewawasam, Andrew Nickel, Kyle E. Parcella, Kap-Sun Yeung, Louis S. Chupak
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Abstract
The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Claims10
A compound of formula V
- where:
- R1 is halo, alkyl, cycloalkyl, alkoxy, oxazolidinonyl, dioxothiazinyl, R5R6N,
- piperidinonyl substituted with 1
- substituent, pyrrolyl substituted with 1
- substituent, or phenyl where said phenyl is substituted with 1-2 substituents selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, carboxy, and CONR7R8, and where said phenyl is also substituted with 0-2 halo, alkyl, alkoxy, pyridinyl, phenyl or halophenyl substituents;
- R2 is hydrogen, halo, alkyl, cycloalkyl, alkoxy, or R5R6N;
- R3 is cyano, alkoxycarbonyl, (cycloalkyl)oxycarbonyl, (alkylsulfonyl)aminocarbonyl, CONR11R12, (R13)(R14)NCONH, triazolyl, thiazolyl, or tetrazolyl;
- R4 is phenyl substituted with 0-2 halo;
- R5 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, benzyl, alkylcarbonyl, haloalkylcarbonyl, phenylcarbonyl, (alkoxyphenyl)carbonyl, alkylsulfonyl, phenylsulfonyl, (alkoxyphenyl)sulfonyl or (haloalkoxyphenyl)sulfonyl;
- R6 is hydrogen, alkyl, hydroxyalkyl, or alkoxyalkyl;
- or R5 and R6 taken together with the nitrogen to which they are attached is oxazolidinonyl or dioxothiazinyl;
- R7 is hydrogen, alkyl,
- R8 is hydrogen or alkyl;
- R9 is hydrogen or alkyl;
- R10 is hydrogen or alkyl;
- or R9 and R16 taken together is ethylene, propylene, butylene, or pentylene;
- R11 is hydrogen or alkyl;
- R12 is hydrogen or alkyl;
- or R11 and R12 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
- R13 is hydrogen or alkyl;
- R14 is hydrogen or alkyl;
- or R13 and R14 taken together with the nitrogen to which they are attached is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
- R15 is alkyl or cycloalkyl;
- R16 is hydrogen, halo, alkyl, or alkoxy;
- R17 is hydrogen, halo, alkyl, or alkoxy;
- and
- Ar1 is isoxazolyl, oxadiazolyl, pyridinyl, pyrimidinyl, or phenyl, and is substituted with 0-1 halo, alkyl, or phenyl substituents;
- or a pharmaceutically acceptable salt thereof.
25 more elements
Dependencies are inferred from the claim text.