Cinnamoyl-piperazine derivatives and their use as par-1 antagonists
AssigneePierre Fabre Medicament
InventorsMichel PEREZ, Marie Lamothe, Bruno Le Grand, Robert Letienne
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Abstract
The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2; R2 represents: hydrogen or halogen; n represents: 1 or 2; R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.
Claims21
Compounds of general formula (I):
- wherein:
- R1 represents:
- halogen, CN or NO2;
- R2 represents:
- hydrogen or halogen;
- n represents:
- 1 or 2;
- R3 represents:
- phenyl substituted by one or more halogens or C1-C6 alkyls;
- or a cyclohexyl;
- as well as the therapeutically-acceptable salts or solvates thereof.
The use of an antagonist PAR 1 for the manufacture of a drug for the curative and/or preventive treatment of atrial fibrillation.
Dependencies are inferred from the claim text.