METHOD OF IMPROVING TRANSPLANT FUNCTION USING SOLUBLE COMPLEMENT RECEPTOR TYPE I (sCR1)
AssigneeCelldex Therapeutics, Inc.
InventorMarc Antonius Seelen
Life of this patent
Estimating the term…
Abstract
A method is disclosed for inhibiting complement activation in brain-dead organ donors, particularly kidney donors, which leads to improvement of organ function of transplanted organs in recipients. The method involves administration of a complement inhibitory protein, specifically a soluble complement receptor type I (sCR1) polypeptide to the donor prior to harvesting the organ for transplant.
Claims7
A method for preparing a transplant organ from a brain-dead organ donor to improve organ function in a recipient of said transplanted organ from said brain-dead organ donor, said method comprising administering to a brain-dead mammalian donor an effective amount to inhibit systemic and/or local complement activation of a soluble complement receptor type I (sCR1) polypeptide prior to excision of said organ from said donor.
A method for improving transplant organ function in a transplant organ recipient comprising:
- administering to a brain-dead organ donor an amount of a soluble CR1 polypeptide effective to inhibit systemic and/or local organ donor complement activation;
- removing an organ from said brain-dead organ donor;
- and
- transplanting said organ into a recipient.
A method of treating transplant organ rejection in a recipient of a transplant from a brain-dead organ donor, said method comprising administering to said brain-dead mammalian donor an effective amount of a soluble complement receptor type I (sCR1) polypeptide.
Dependencies are inferred from the claim text.