Methods for Treating Autoimmune Disorders, and Reagents Related Thereto
AssigneesThe Brigham and Women's Hospital, Inc., Trustees of Tufts College
InventorsWilliam W. Bachovchin, Vijay K. Kuchroo
Life of this patent
Estimating the term…
Abstract
The invention generally relates to improved methods for the treatment or prophylaxis in animal subjects (including humans) of autoimmune disorders including Type I diabetes, septic shock, multiple sclerosis, inflammatory bowel disease (IBD) and Crohn's disease.
Claims19
1-43. (canceled)
A method of treating an animal afflicted with Type 1 diabetes, comprising administering to said animal a therapeutically effective amount of a composition comprising an inhibitor of DPIV or a salt thereof in an amount sufficient to suppress the immune system, thereby slowing the rate of destruction of pancreatic beta cells.
A method of treating an animal afflicted with Type 1 diabetes, comprising administering to said animal a therapeutically effective amount of a composition comprising an inhibitor of DPIV or a salt thereof in an amount sufficient to suppress the immune system, thereby stimulating β-cell growth and differentiation.
A method of treating an animal afflicted with Type 1 diabetes, comprising administering to said animal a therapeutically effective amount of a composition comprising an inhibitor of DPIV or a salt thereof in an amount sufficient to suppress the immune system, thereby slowing the rate of destruction of pancreatic beta cells, wherein said inhibitor has an EC50 in the μM range or less.
A method of treating an animal afflicted with Type 1 diabetes, comprising administering to said animal a therapeutically effective amount of a composition comprising an inhibitor of DPIV or a salt thereof in an amount sufficient to suppress the immune system, thereby stimulating β-cell growth and differentiation, wherein said inhibitor has an EC50 in the μM range or less.
Dependencies are inferred from the claim text.