Slow-acting insulin preparations

Aqueous An aqueous pharmaceutical formulations formulation comprising an insulin analog of the formula I

• where
• A0 is Lys or Arg;
• A5 is Asp, Gln or Glu;
• A15 is Asp, Glu or Gln;
• A 18 is Asp, Glu or Asn;
• B-1 is Asp, Glu or an amino group;
• B0 is Asp, Glu or a chemical bond;
• B1 is Asp, Glu or Phe;
• B2 is Asp, Glu or Val;
• B3 is Asp, Glu or Asn;
• B4 is Asp, Glu or Gln;
• B29 is Lys or a chemical bond;
• B30 is Thr or a chemical bond;
• B31 is Arg, Lys or a chemical bond;
• B32 is Arg-amide, Lys-amide or an amino group,
• where two amino acid residues of the group containing A5, A15, A18, B-1, B0, B1, B2, B3, and B4, simultaneously and independently of one another, are Asp or Glu, or a pharmacologically tolerable salt thereof;
• and comprising
• 0.001 to 0.2 mg/ml of zinc,
• 0.1 to 5.0 mg/ml of a preservative, and
• 5.0 to 100 mg/ml of an isotonicity agent, and
• whose pH is 5 or less.