Methods and compositions for promoting regeneration by increasing intracellular sodium concentration
AssigneeTufts University
InventorMichael Levin
Life of this patent
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Abstract
The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell.
Claims36
A method of promoting one or more of proliferation or differentiation, comprising contacting a cell culture with an effective amount of an agent to increase intracellular sodium concentration in cells of said cell culture, wherein said agent is selected from a sodium ionophore, or insulin, or both, and wherein the agent induces Na+ influx into said cell, thereby promoting one or more of proliferation or differentiation.
A method of promoting tissue regeneration, comprising contacting a cell culture with an effective amount of an agent to increase intracellular sodium concentration in cells of said cell culture, wherein said agent is selected from a sodium ionophore, or insulin, or both, and wherein the agent induces Na+ influx into said cell, thereby promoting tissue regeneration.
A method for promoting one or more of proliferation or differentiation, comprising administering an effective amount of an agent, wherein said agent is selected from a sodium ionophore, or insulin, or both, and wherein the agent induces Na+ influx into cells, thereby promoting one or more of proliferation or differentiation.
A method for promoting tissue regeneration, comprising administering an effective amount of an agent, wherein said agent is selected from a sodium ionophore, or insulin, or both, and wherein the agent induces Na+ influx into said cells, thereby promoting tissue regeneration.
A method for inhibiting growth and/or metastasis of tumor cells, comprising contacting tumor cells with an agent selected from one or more of an ionophore or a sodium channel modulator that promotes sodium efflux.
A method of promoting one or more of proliferation or differentiation, comprising administering an amount of an agent effective to increase intracellular sodium concentration in a cell, wherein said agent induces Na+ influx into said cell, thereby promoting one or more of proliferation or differentiation.
A method of promoting tissue regeneration, comprising administering an amount of an agent effective to increase intracellular sodium concentration in a cell, wherein said agent induces Na+ influx into said cell, thereby promoting cell proliferation to promote tissue regeneration.
36-90. (canceled)
Dependencies are inferred from the claim text.