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AssigneeNatonal University Corporation Hamamatsu University School of Medicine
InventorsNorio Mori, Kazuhiko Nakamura, Katsuaki Suzuki, Kenji Tsuchiya, Keiko Iwata, Hideo Matsuzaki
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The present invention relates to a method for determining the degree of risk of onset of autism, comprising the step of measuring the triglyceride concentration or the cholesterol concentration in a very low-density lipoprotein fraction of plasma or serum isolated from a subject, or the triglyceride concentration or the cholesterol concentration of plasma or serum. In addition, the present invention provides a kit for determining the degree of risk of onset of autism and a method for screening for a candidate substance for agents for treating autism using a non-human mammal, in which the above described method is utilized.
A method for determining the degree of risk of onset of autism, comprising the step of measuring a very low-density lipoprotein contained in plasma or serum isolated from a subject, wherein the degree of risk of onset of autism of the subject is determined to be high when the triglyceride concentration in a very low-density lipoprotein fraction of the plasma or serum is 60 mg/dl or less.
A kit for determining the degree of risk of onset of autism, comprising one or more enzymes selected from the group consisting of lipoprotein lipase, glycerol kinase, glycerol-3-phosphate oxidase, peroxidase, ascorbate oxidase, pyruvate kinase, and lactate dehydrogenase;
A method for screening for a candidate substance for agents for treating autism, comprising the steps of:
A method for determining the degree of risk of onset of autism, comprising the step of measuring a very low-density lipoprotein contained in plasma or serum isolated from a subject, wherein the degree of risk of onset of autism of the subject is determined to be high when the cholesterol concentration in a very low-density lipoprotein fraction of the plasma or serum is lower than a standard value minus standard deviation of cholesterol concentrations in very low-density lipoprotein fractions of plasma or serum of healthy individuals.
A method for determining the degree of risk of onset of autism, comprising the step of measuring the cholesterol concentration and/or the triglyceride concentration in plasma or serum isolated from a subject, wherein the degree of risk of onset of autism of the subject is determined to be high when the measured concentration of cholesterol is lower than a standard value minus standard deviation of cholesterol concentrations in healthy individuals, and/or when the measured concentration of triglyceride is lower than a standard value minus standard deviation of triglyceride concentrations in healthy individuals.
A kit for determining the degree of risk of onset of autism, comprising cholesterol oxidase, peroxidase, and a coloring agent.
Dependencies are inferred from the claim text.