Combination Therapy for Bipolar Disorder
AssigneeComgenRx, Inc.
InventorsBryan T. Oronsky, Neil C. Oronsky
Life of this patent
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Abstract
Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.
Claims30
1-29. (canceled)
A composition comprising (i) buprenorphine or a pharmaceutically acceptable salt thereof and (ii) a second active agent in a single dosage form, wherein the second active agent comprises an antipsychotic agent, an atypical antipsychotic agent, an antiepileptic agent, lithium, a P-450 CYP3A4 inhibitor, a P-450 CYP2D6 inhibitor, salts and acids thereof, and combinations thereof.
31-35. (canceled)
38-51. (canceled)
A method for treating a bipolar condition and subtypes thereof in a subject, the subject experiencing at least one episode of racing thoughts, comprising administering buprenorphine or a pharmaceutically acceptable salt thereof to the subject to alleviate the racing thoughts.
56-59. (canceled)
63-64. (canceled)
68-83. (canceled)
A kit for treating a bipolar condition and subtypes thereof comprising:
- a plurality of buprenorphine dosage forms;
- at least one second dosage form comprising a second active agent;
- a housing;
- and instructions for taking the dosage forms for racing thoughts associated with the depressed phase of the bipolar condition or subtype thereof, and according to a predetermined dosing regimen, wherein the housing is configured to organize the dosage forms according to the predetermined dosing regimen.
87-94. (canceled)
(canceled)
99-123. (canceled)
125-129. (canceled)
Dependencies are inferred from the claim text.