Natural product inhibitors of 3dg
OwnerAnnette Tobia, Marcy Alice +2inventors
InventorsAnnette Tobia, Marcy Alice, Bangying Su, Takashi Niwa
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Abstract
Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and/or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and/or elasticity of aging skin, are also disclosed.
Claims29
A method for the treatment or prophylaxis of a condition or disease state which is alleviated by inhibiting the enzymatic conversion of fructoselysine to fructoselysine-3-phosphate, in a patient in need of said treatment or prophylaxis, said method comprising administering to said patient at least one natural product having as a component thereof an inhibitor of said enzymatic conversion of fructoselysine to fructoselysine-3-phosphate, in an amount effective to inhibit said conversion.
A method of preventing, ameliorating and/or reversing the intrinsic and/or extrinsic aging of skin, said method comprising topically applying to said aging skin a composition comprising at least one natural product having as a component thereof an inhibitor of the enzymatic conversion of fructoselysine to fructoselysine-3-phosphate, in an amount effective to inhibit said conversion.
A method of improving the appearance, texture, or elasticity of aging skin, said method comprising topically applying to said aging skin a composition comprising at least one natural product having as a component thereof an inhibitor of the enzymatic conversion of fructoselysine to fructoselysine-3-phosphate, in an amount effective to inhibit said conversion.
A method of treating skin damage due to oxidative stress and/or the production of AGEs, said method comprising topically applying to said damaged skin a composition comprising a natural product having as a component thereof an inhibitor of the enzymatic conversion of fructose-lysine to fructose-lysine-3-phosphate, in an amount effective to inhibit said conversion.
A method of enhancing the purity of preparations containing glucosamine and its pharmaceutically acceptable salts and derivatives as a food, cosmetic, pharmaceutical or dietary supplement ingredient, said method comprising reducing the 3-deoxyglucosone (3DG) content thereof.
-34. (canceled)
A topical composition comprising at least one natural product comprising an agent that acts to inhibit the enzymatic production of 3-deoxyglucosone from fructoselysine, and at least one dermatologically acceptable excipient.
A topical composition comprising at least one natural product comprising an inactivator of 3-deoxyglucosone, and at least one dermatologically acceptable excipient.
Dependencies are inferred from the claim text.